To identify risk factors for further deterioration of central visual function in the eye with advanced glaucoma.

Patients with advanced glaucoma with well-controlled intraocular pressure (IOP), mean deviation (MD) of Humphrey Field Analyzer 242 Program (HFA 242) of 20 decibels or less, and visual acuity (BCVA) of 20/40 or more The HFA102 test and BCVA examination were performed every 6 months and the HFA 242 test every 12 months for 5 years. The Cox proportional hazards model was used to identify risk factors for deterioration of HFA102 and 242 results and BCVA. Deterioration of HFA 102 results was indicated by the presence of the same ≥3 points with a negative overall slope of 1 dB / year or less at P & lt. A result of 0.01 for 3 or more consecutive tests, a result of HFA 242 increases the score of Advanced Glaucoma Intervention Study (AGIS) by 2 or more in 2 or more consecutive tests, and a score of BCVA increases by 0.2 or more in log MAR. ≥ Two consecutive tests. A total of 175 eyes with progressive glaucoma from 175 patients (mean age 64.1 years; mean baseline IOP 13.2 mmHg; mean logMAR 0.02; mean HFA242 and 102MD, 25.9 and 22.9 decibels, respectively) were included.  The average IOP during the follow-up visit was 13.0 mmHg. The probabilities of worsening HFA 102 and 242 and BCVA results were 0.269 ± 0.043 (standard error), 0.173 ± 0.031, and 0.194 ± 0.033, respectively, after 5 years. A lower baseline BCVA (P = 0.012) was significantly associated with further deterioration of HFA102 results. Better HFA242MD (P & lt; 0.001) and use of systemic antihypertensive drugs (P = 0.009) were significantly associated with further deterioration of HFA242 results and a larger proportion of β-papillary atrophy / disc region (P & lt; 0.001). Was there Systemic antihypertensive drug use (P = 0.025) and lower BCVA (P = 0.042) were each significantly associated with further exacerbation of BCVA. In the eyes of progressive glaucoma with well-controlled IOP and BCVA, the β-papillary atrophy region/discretion ratio and the use of systemic antihypertensive drugs were important prognostic factors for further deterioration of central visual function.


 

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