Longitudinal Changes in Scotopic and Mesopic Macular Function as Assessed with Microperimetry in Patients with Stargardt Disease

 

The Nidek MP1S device was used to measure central 20 ° macular sensitivity under mesopic and scotopic conditions. Mean deviations (MD) from normal value for mesopic macular sensitivity for fovea (within 2 ° eccentricity) and extrafovea (4 ° 10 ° eccentricity) and the MD for scotopic sensitivity for extra fovea were calculated. Linear mixed effects models were used to estimate mesopic and scotopic changes and the mMD was 10.7 dB (p <0.001). Longitudinally, all eyes showed a statistically significant deterioration trend: the rates of foveal mMD and extrafoveal mMD and some were 0.72 (95% CI 0.37 to 1.07), 0.86 (95% CI: 0.58 to 1.14) and 1.12 (95% CI.). : 0.66 to 1.57) dB / year. In STGD1, the loss of scotopic macular function preceded the extrafovea and was faster than the loss of mesopic macular function. Scotopic and mesopic macular sensitivities using microperimetry provide alternative visual function results for STGD1 treatment studies. At baseline, all eyes had a larger sMD and the difference between extrafoveal sMD and mMD was 10.7 dB (p <0.001). Longitudinally, all eyes showed a statistically significant deterioration trend: the rates of foveal mMD and extrafoveal mMD and sMD were 0.72 (95% CI 0.37 to 1.07), 0.86 (95% CI: 0.58 to 1.14) and 1.12 (95% CI.).: 0.66 to 1.57) dB / year.


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  1. Ophthalmology, Ophthalmic Equipment Manufacturers & SuppliersOctober 22, 2021 at 10:52 PM

    Thanks for sharing this wonderful blog with us. Nice post with great information and it is indeed informative and useful.

    Ophthalmology Equipment Suppliers

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