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Prominent protuberances: A peep over corneal striae

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A 4-year-old man showed recent binocular (BE) visual impairment, pain, and redness. He had been taking topical steroids for two years because of allergic conjunctivitis. On the test, uncorrected visual acuity was 20/120 and 20/200 for the right eye (RE) and left eye (LE), respectively. BE SLE showed conjunctival congestion and upper tarsal papillae. Corneal findings of microcystic epithelium and interstitial edema (LE> RE) were recorded with horizontal muscle and posterior corneal pigmented bands. The fundus showed almost perfect cupping in BE. BE's IOP was 32mmHg. The child was born by caesarean section at maturity, with a history of benign birth and development. The expression was asymmetrical. The keratometry value does not indicate the inclination of the cornea. Front eye optical coherence tomography (ASOCT) of RE showed hyperreflexive Descemet's membrane (DM) with prominent endothelial protrusions, and the left eye showed local stromal thickening with endothelial protr

Independent and integrated ophthalmology – where justice and excellence meet

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About 2.2 billion people worldwide are visually impaired, at least half of whom are preventable. Current estimates of preventable causes of moderate to severe visual impairment or blindness include untreated refractive error (88.4 million), cataracts (94 million), glaucoma (7.7 million), corneal opacity (4.2 million), Includes diabetic glaucoma (3.9 million) and trachoma (3.9 million). 2 million), but mostly due to uncorrected presbyopia (826 million). Of gross domestic product.  The World Health Organization's resolution on "Integrated Human-Centered Ophthalmology (IPEC), Including Preventive Blindness and Visual Impairment". At the core of the resolution is to make IPEC the optimal model and ensure its widespread implementation. It is estimated that about two-thirds of the population of India may require free or subsidized eye care, and if they have no such access, they may suffer marginalization and exclusion. Affordable and accessible high-quality care delivered by t

Utilizing human intelligence with artificial intelligence, we use machine learning of human loops to detect glaucoma fundus images.

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To overcome the artificial intelligence (AI) black box dilemma to diagnose glaucoma damage, we applied a new convolutional neural network (CNN) of TrueColor confocal fundus images. With human-in-the-loop (HITL) data annotations, this CNN architecture neural network is useful not only for diagnosing glaucoma but also for predicting and locating detailed signs of glaucoma fundus, including: B. Splinter hemorrhage, glaucomatous optic nerve atrophy, vertical glaucomatous coupling, peripapillary atrophy and retinal nerve fiber layer defect (RNFL). The training was performed on a carefully selected private dataset of 1,400 high-resolution confocal fundus images. Of these, 1,120 (80%) are dedicated to training and 280 (20%) are dedicated to testing. We used a specially trained object detection method based on You Only Look Once version 5 (YOLOv5) to pinpoint the underlying condition. The 26 predefined conditions were annotated by a team of humans (composed of two glaucoma specialists and two

Application of mydriasis and eye steering in ultrawide field imaging for detecting peripheral retinal lesions in myopic patients

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To compare mydriatic and eye-steering ultrawide field imaging (UWFI) with standard non-mydriatic UWFI examination in detecting peripheral retinal lesions in a myopic patient's cross-sectional observational study. 220 eyes from 110 myopia patients with known peripheral retinal lesions in at least one eye were recruited for Goldman 3 mirror contact lens examination. Using Optomap UWFI (Daytona, Optos, UK), non-mydriatic standard and eye-steering UWFI images were taken in the center and eye-steered in the up, down, nose, and temporal gaze directions. Standard and eye steering mydriatic UWFIs were recorded with a central line of sight and four different peripheral lines of sight. We compared the sensitivities of detecting peripheral retinal lesions at various UWFI settings. 141 (64.09%) eyes had peripheral retinal lesions. Sensitivity to detect low to high peripheral lesions is 41.84% (95% CI 33.62% to 50.54%) with standard non-mydriatic UWFI settings and 52.48% (95% CI 44, 08% to 60.7

To identify risk factors for further deterioration of central visual function in the eye with advanced glaucoma.

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Patients with advanced glaucoma with well-controlled intraocular pressure (IOP), mean deviation (MD) of Humphrey Field Analyzer 242 Program (HFA 242) of 20 decibels or less, and visual acuity (BCVA) of 20/40 or more The HFA102 test and BCVA examination were performed every 6 months and the HFA 242 test every 12 months for 5 years. The Cox proportional hazards model was used to identify risk factors for deterioration of HFA102 and 242 results and BCVA. Deterioration of HFA 102 results was indicated by the presence of the same ≥3 points with a negative overall slope of 1 dB / year or less at P & lt. A result of 0.01 for 3 or more consecutive tests, a result of HFA 242 increases the score of Advanced Glaucoma Intervention Study (AGIS) by 2 or more in 2 or more consecutive tests, and a score of BCVA increases by 0.2 or more in log MAR. ≥ Two consecutive tests. A total of 175 eyes with progressive glaucoma from 175 patients (mean age 64.1 years; mean baseline IOP 13.2 mmHg; mean logM

Long-Term Postoperative Structural and Functional Evaluation in Myopic Foveoretinal Detachment

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Avoidable severe visual sequelae are common in severe myopic eyes. We analyzed the postoperative incidence of myopia traction macular disease (MTM) and the long-term postoperative structural and functional findings of myopia foveal retinal detachment (FRD) after macular surgery. Retrospectively at the surgeon for 35 severe myopic eyes in 31 patients who had foveal preservation technology to remove the internal limiting membrane by foveal FRD between October 2016 and April 2020, A series of continuous, relatively interventional, multicenter controlled cases was performed. Chromatic campimetry and multifocal electrocardiography were performed using microperimetry. The main results were surgical success and frequency of myopia FRD progression. The average evolution time for myopia FRD was 6.2 ± 3.5 months. The average follow-up period was 23.9 ± 12.1 months. The average time for FRD resolution for myopia was 5 ± 2.1 weeks. Using a pair sample permutation test, we found that surgery was a

Longitudinal Changes in Scotopic and Mesopic Macular Function as Assessed with Microperimetry in Patients with Stargardt Disease

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  The Nidek MP1S device was used to measure central 20 ° macular sensitivity under mesopic and scotopic conditions. Mean deviations (MD) from normal value for mesopic macular sensitivity for fovea (within 2 ° eccentricity) and extrafovea (4 ° 10 ° eccentricity) and the MD for scotopic sensitivity for extra fovea were calculated. Linear mixed effects models were used to estimate mesopic and scotopic changes and the mMD was 10.7 dB (p <0.001). Longitudinally, all eyes showed a statistically significant deterioration trend: the rates of foveal mMD and extrafoveal mMD and some were 0.72 (95% CI 0.37 to 1.07), 0.86 (95% CI: 0.58 to 1.14) and 1.12 (95% CI.). : 0.66 to 1.57) dB / year. In STGD1, the loss of scotopic macular function preceded the extrafovea and was faster than the loss of mesopic macular function. Scotopic and mesopic macular sensitivities using microperimetry provide alternative visual function results for STGD1 treatment studies. At baseline, all eyes had a larger sMD and